Unsubstituted Phenols
Medchemexpress LLC CPPHA | 693288-97-0 | 98.1% | 406.82 | 100 MG
CPPHA is a potent and selective positive allosteric modulator (PAM) of the mGluR5 and mGluR1 (metabotropic glutamate receptor). It can potentiate responses of mGluR5 and mGluR1 to the activation of these receptors and is developed for the research of central nervous system disorders.
- Potentiates responses of mGluR5 and mGluR1 to activation
- Causes concentration-dependent potentiation of human mGluR5 CHO cells to agonists
- Potentiates threshold response to glutamate in fluorometric Ca2+ assays
- Potentiates DHPG-induced increase in phosphorylation of ERK and CREB
Medchemexpress LLC Terbutaline (sulfate) | 23031-32-5 | 100.0% | 500 MG
Terbutaline sulfate is an orally active β2-adrenergic receptor agonist and an active metabolite of bambuterol. It is primarily used in asthma symptom research.
- Acts as an orally active β2-adrenergic receptor agonist.
- Functions as an active metabolite of bambuterol.
- Enhances MKP-1 expression in activated mouse macrophages.
- Reduces the phosphorylation of p38 MAPK in J774 macrophages.
- Improves allodynia in ob/ob mice.
Medchemexpress LLC Liquiritigenin-7-O-β-D-glucopyranosyl-(1→2)-β-D-apiofuranoside | 135432-48-3 | 10 MG
Liquiritigenin-7-O-β-D-glucopyranosyl-(1→2)-β-D-apiofuranoside, also known as Liquiritigenin-7-apiosylglucoside, is a flavonoid isolated from the roots of Glycyrrhiza. It is recognized for exhibiting weaker cytotoxicity against various tumor cells and normal cells. This product is strictly for research use only and not intended for sale to patients.
- Source: Isolated from the roots of Glycyrrhiza.
- Activity: Flavonoid with weaker cytotoxicity against several tumor cells and normal cells.
- Purity: 99.74% confirmed.
- Appearance: Solid, light yellow to yellow in color.
- In vitro solubility: 100 mg/mL in DMSO (181.65 mM).
- In vivo solubility: Can be dissolved in various solvent systems such as 10% DMSO, 40% PEG300, 5% Tween-80, 45% Saline; 10% DMSO, 90% (20% SBE-β-CD in Saline); or 10% DMSO, 90% Corn Oil, with solubilities generally ≥ 2.5 mg/mL (4.54 mM).
Medchemexpress LLC Kaempferol 3-O-sophoroside | 19895-95-5 | 610.52 | 5 MG
Kaempferol 3-O-sophoroside is an orally active derivative of Kaempferol. It exhibits anti-inflammatory, analgesic, and antidepressant effects by inhibiting the cell surface receptor toll-like receptor (TLR) 2/4 and blocking NF-κB expression and TNF-α production. It also promotes brain-derived neurotrophic factor (BDNF) production and enhances autophagy by binding to AMP-activated protein kinase (AMPK).
- Orally active derivative of Kaempferol.
- Exhibits anti-inflammatory, analgesic, and antidepressant effects.
- Acts as an inhibitor of the cell surface receptor toll-like receptor (TLR) 2/4.
- Blocks the activation of NF-κB expression and the production of TNF-α.
- Promotes brain-derived neurotrophic factor (BDNF) production.
- Enhances autophagy by binding to AMP-activated protein kinase (AMPK).
- Considered promising for research in inflammation and neurodegenerative diseases.
Medchemexpress LLC Ginkgolic acid C17:1 | 111047-30-4 | 5 MG
Ginkgolic acid C17:1 is a fatty acid synthase (FAS) inhibitor with an IC50 of 10.5 μM. It exhibits anti-tumor activity by inhibiting the phosphorylation of STAT3 and inducing apoptosis. This compound also blocks the interaction between S-RBD and ACE2, showing anti-SARS-CoV-2-S pseudovirus activity. Additionally, it inhibits the biofilm formation of enterohemorrhagic Escherichia coli and Staphylococcus aureus.
- Inhibits fatty acid synthase (FAS).
- Exhibits anti-tumor activity.
- Induces apoptosis.
- Blocks S-RBD and ACE2 interaction.
- Shows anti-SARS-CoV-2-S pseudovirus activity.
- Inhibits biofilm formation of enterohemorrhagic Escherichia coli.
- Inhibits biofilm formation of Staphylococcus aureus.
Medchemexpress LLC Apigenin 7-glucoside | 578-74-5 | MFCD00016787 | 432.38 | 100 MG
Apigenin 7-glucoside | 578-74-5 | MFCD00016787 | 432.38 | 100 MG
Medchemexpress LLC Liquiritin apioside | 74639-14-8 | 550.51 | 5 MG
Liquiritin apioside is an orally active inhibitor of the TRPV1 receptor, which selectively inhibits the laryngeal chemoreflex (LCR) without significantly affecting the mechanoreflex (LMR). It achieves this by attenuating reactive oxygen species (ROS) and NADPH oxidase, thereby weakening the interaction between ROS and TRPV1. This compound is valuable in research related to respiratory diseases and has shown potential in ameliorating colitis.
- Selectively inhibits laryngeal chemoreflex
- Does not significantly affect mechanoreflex
- Attenuates reactive oxygen species and NADPH oxidase
- Used in respiratory disease research
- Ameliorates DSS-induced colitis in mice
Medchemexpress LLC Isosilybin | 72581-71-6 | 482.44 | 50 MG
Isosilybin is a flavonoid derived from Silybum marianum that functions as an inhibitor of CYP3A4 induction. It is intended for research use only.
- Inhibits PXR-mediated CYP3A4 induction with an IC50 of 74 μM.
- Acts as a stronger inhibitor of PXR-mediated CYP3A4 induction compared to silybin.
- Exhibits anti-prostate cancer activity through cell cycle arrest and apoptosis induction.
- Increases phosphorylation of Akt and Mdm2, associated with androgen receptor degradation.
- Enhances the formation of a complex between Akt, Mdm2, and AR.
- Can significantly activate PPARγ and causes transactivation of a PPARγ-dependent luciferase reporter.
Medchemexpress LLC Loureirin C | 116384-24-8 | 5 MG
Loureirin C is a solid, white to off-white compound classified as a phenol and polyphenol, initially sourced from plants. It exhibits a range of biological activities.
- Anti-bacterial activity
- Anti-spasmodic activity
- Anti-inflammatory activity
- Analgesic activity
- Anti-diabetic activity
- Anti-tumor activity
Medchemexpress LLC Dibenzo[a,c]cycloocten-1-ol, 5,6,7,8-tetrahydro-2,3,10,11,12-pentamethoxy-6,7-dimethyl- | 69363-14-0 | 402.48 | 100 MG
Dibenzo[a,c]cycloocten-1-ol, 5,6,7,8-tetrahydro-2,3,10,11,12-pentamethoxy-6,7-dimethyl- | 69363-14-0 | 402.48 | 100 MG